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Félix de Lapersonne (29 September 1853, Toulouse – 4 July 1937) was a French ophthalmologist.
Born in Toulouse, he served as interne and chef de clinique (i.e. residency) under Photinos Panas (1832–1903) in the ophthalmology clinic at the Hôtel-Dieu de Paris. In 1890 he was appointed professor of ophthalmology to the faculty at Lille, serving as dean until 1901. Afterwards, he returned to Paris, where he worked as professor of clinical ophthalmology. He was a member of the Académie de Médecine, and a chevalier of the Légion d'honneur.As an ophthalmologist, Lapersonne made contributions in his investigations of syphilitic optic neuritis, and ophthalmoneuromyelitis (Devic's disease). "De Lapersonne's capsulo-iridotome", a punch forceps used in eye surgery, is named after him.