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Simone Del Duca (18 July 1912 – 16 May 2004) was a French businesswoman, a member of the Académie des Beaux-Arts, and major philanthropist. Married to French publishing magnate Cino Del Duca, on his death in 1967 she was left with a considerable fortune. Although she remained on the board of directors of her late husband's companies, Simone Del Duca devoted a great deal of her time to philanthropic causes. In 1969 she established a prestigious literary prize in her husband's name. The Prix mondial Cino Del Duca provides a substantial cash prize and was made open to qualified persons from anywhere in the world.
Simone Del Duca's charitable activities increased to where in 1975 she created the Simone and Cino Del Duca Foundation. The Foundation's primary involvements gave support for scientific research and after being made a member of the Académie des Beaux-Arts in 1994 she funded two major prizes in visual arts and music awarded through the Académie. Simone Del Duca's philanthropic work was recognized by the government of France who made her a commander of the Legion of Honor.