21st-century American male actors

Justin Willman Chambers (born July 11, 1970) is an American actor and former model. He is best known for his role as Dr. Alex Karev in the ABC television medical drama Grey's Anatomy from 2005 to 2020. Born in Ohio, he went to Southeastern High School, South Charleston, and later studied acting at New York's HB Studio. Chambers began modeling after being approached by a modeling scout in Paris. He went on to represent fashion brands including Calvin Klein, Armani, and Dolce & Gabbana. Chambers began his acting career with a recurring role in the soap opera Another World and made his feature film debut with a supporting role in the comedy drama Liberty Heights (1999).
In 2005, he was cast as Dr. Alex Karev in the ABC medical drama series Grey's Anatomy. Chambers gained widespread recognition as the series progressed and the character became one of the most popular from the hit series, earning multiple nominations and the 2017 Best TV Network Drama Actor at the People's Choice Awards as well as nominations for the Screen Actors Guild Award.

Joshua Paul Dallas (born December 18, 1978) is an American actor. He is best known for his roles as Prince Charming/David Nolan in the ABC television series Once Upon a Time and starring as Ben Stone in the hit NBC/Netflix sci-fi drama series Manifest.

Sasha Sergei Mitchell (born July 27, 1967) is an American actor best known for his television roles as Cody Lambert on Step by Step and James Beaumont on Dallas. He also played the role of David Sloane in three of the four installments of the original Kickboxer film franchise. Mitchell has a black belt in taekwondo.

Robert Boyd Holbrook (born September 1, 1981) is an American actor. He has starred in the Netflix series Narcos (2015–2016) as DEA agent Steve Murphy and The Sandman (2022–) as the Corinthian, as well as in the History miniseries Hatfields & McCoys as "Cap" Hatfield. He starred as Billy in The Skeleton Twins (2014), Peter Kristo in A Walk Among the Tombstones (2014), Donald Pierce in Logan (2017), Quinn McKenna in The Predator (2018), Pinkins in O.G. (2019), Thomas Lockhart in In the Shadow of the Moon (2019), Ty Shaw in Vengeance (2022), and Clement Mansell Justified: City Primeval (2023).

Alden Caleb Ehrenreich (; born November 22, 1989) is an American actor. He began his career by appearing in the television series Supernatural (2005), and in Francis Ford Coppola's films Tetro (2009) and Twixt (2011). Following supporting roles in the 2013 films Blue Jasmine and Stoker, his breakthrough came in 2016 with a lead role in the Coen brothers' comedy Hail, Caesar!, for which he gained praise.
Ehrenreich played Han Solo in Solo: A Star Wars Story (2018) and starred in the dystopian television series Brave New World (2020). In 2023, he had starring roles in the comedy Cocaine Bear and the thriller Fair Play, and a supporting role in Christopher Nolan's biographical film Oppenheimer.

William Joshua Hopkins (born September 12, 1970) is an American actor. Some of his best known roles include Raymond Millbury on Ally McBeal (2001–2002), Grayson Ellis on Cougar Town (2009–2015), and Liam O'Connor on Quantico (2015–2016).

Lawrence Pressman (born David Milton Pressman; July 10, 1939) is an American actor, probably best known for roles on Doogie Howser, M.D., Ladies' Man, a recurring role on Profiler, the title character on Mulligan's Stew and as a fictional scientist in the 1971 film The Hellstrom Chronicle.

Thomas Andrew Franco (born April 14, 1980) is an American actor, artist, and the founder of the Firehouse Art Collective in Berkeley, California. He is the brother of actors James Franco and Dave Franco.

Eric Salter Balfour (born April 24, 1977) is an American actor. He made his film debut in the Lifetime movie No One Would Tell in 1996, followed by the drama Shattered Image (1998), followed by roles in What Women Want (2000) and The Texas Chainsaw Massacre (2003). His roles on television include Milo Pressman on the action-thriller TV series 24, a recurring role in the drama Six Feet Under as Gabriel Dimas, Duke Crocker in Haven, Eddie on The OC, and as Boone in Country Comfort.

Jesse Eden Metcalfe (born December 9, 1978) is an American actor. He is known for his portrayal of John Rowland on Desperate Housewives. Metcalfe has also had notable roles on Passions and played the title role in John Tucker Must Die. He starred as Christopher Ewing in the TNT continuation of Dallas, based on the 1978 series of the same name. From 2016 to 2021, Metcalfe starred as Trace Riley in Hallmark Channel's hit series Chesapeake Shores.