Recipients of the Lasker\u2013DeBakey Clinical Medical Research Award

David_Cushman

David Cushman (November 15, 1939 – August 14, 2000) was born in Indianapolis, Indiana. He was the son of Wayne B. and Mildred M. and married to Linda L. Kranch. They have two children together named Michael and Laura Cushman. Dr. Cushman was an American chemist who co-invented captopril, the first of the ACE inhibitors used in the treatment of cardiovascular disease. With Miguel A. Ondetti, he won the 1999 Lasker Award for: "developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease."

Pierre_Deniker

Pierre Deniker (16 February 1917, in Paris – 17 August 1998) was involved, jointly with Jean Delay and J. M. Harl, in the introduction of chlorpromazine (Thorazine), the first antipsychotic used in the treatment of schizophrenia, in the 1950s. Thorazine had been used in surgical procedures peri-operatively as an anti-nausea medication in France. Patients were noted to be less anxious and calmer. This observation eventually led Deniker to try chlorpromazine with patients who had schizophrenia, where he observed notable improvement in symptoms.
The pharmaceutical company Smith-Kline had purchased the chlorpromazine rights from Rhone-Poulenc in France and had been marketing it as an anti-nausea medication. After Deniker's observations, they sought and received FDA approval in 1954 to market Thorazine for the treatment of schizophrenia.

Robert_A._Good

Robert Alan Good NAM, NAS, AAAS (May 21, 1922 – June 13, 2003) was an American physician who performed the first successful human bone marrow transplant between persons who were not identical twins. He is regarded as a founder of modern immunology.

Alain_Carpentier

Alain Frédéric Carpentier (born 11 August 1933) is a French surgeon whom the President of the American Association for Thoracic Surgery calls the father of modern mitral valve repair. He is most well known for the development and popularization of a number of mitral valve repair techniques. In 1996, he performed the first minimally invasive mitral valve repair in the world and in 1998 he performed the first robotic mitral valve repair with the DaVinci robot prototype. He is the recipient of the 2007 Lasker Prize.