People from Des Moines

Stanley H. Biber (May 4, 1923 – January 16, 2006) was an American physician who was a pioneer in sex reassignment surgery, performing thousands of procedures during his long career.

James Clarence Irwin (June 7, 1929 – March 21, 2018) was a vice admiral in the United States Coast Guard who served as Vice Commandant from 1986 to 1988. He had been commander of the 5th Coast Guard District and Chief of the Office of Reserve at Headquarters, Coast Guard. After his term as vice commandant, he served as Commander, Joint Task Force FOUR (a predecessor agency to Joint Interagency Task Force South) and Coast Guard Atlantic Area (appointed 1989) and U.S. Maritime Defense Zone Atlantic (from 1988 to 1989).

Lois Cowles Harrison (June 23, 1934 – June 6, 2013) was a civic leader, women's rights activist, and philanthropist.

Neil Clark Warren (born September 18, 1934) is an American clinical psychologist, Christian theologian, seminary professor and co-founder of the online relationship sites eHarmony and Compatible Partners.
In 1995, Warren and his son-in-law, Greg Forgatch, created Neil Clark Warren & Associates, a company which offers seminars and teaching tools based on Warren's books. In early 2000, they established eHarmony, an online compatibility matching service which gained two million users in its first three years. After retiring in 2007, Warren came out of retirement in July 2012, returning as the chief executive of eHarmony.