20th-century American biochemists

Linus_Carl_Pauling

Linus Carl Pauling ( PAW-ling; February 28, 1901 – August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger, and Karl Barry Sharpless). Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie.Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure. Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of Rosalind Franklin, James Watson, Francis Crick, and Maurice Wilkins on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms.In his later years, he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy, and dietary supplements, especially ascorbic acid (commonly known as Vitamin C). None of his ideas concerning the medical usefulness of large doses of vitamins have gained much acceptance in the mainstream scientific community. He was married to the American human rights activist Ava Helen Pauling.

David_Cushman

David Cushman (November 15, 1939 – August 14, 2000) was born in Indianapolis, Indiana. He was the son of Wayne B. and Mildred M. and married to Linda L. Kranch. They have two children together named Michael and Laura Cushman. Dr. Cushman was an American chemist who co-invented captopril, the first of the ACE inhibitors used in the treatment of cardiovascular disease. With Miguel A. Ondetti, he won the 1999 Lasker Award for: "developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease."

Karl_Slotta

Karl Heinrich Slotta (May 12, 1895 in Breslau, Germany (now Wrocław, Poland) – July 17, 1987 in Coral Gables, Florida), was a biochemist. His discovery of progesterone and its relationship to ovulation led to the development of birth control pills.