Mexican people of American descent

Josefina Niggli (1910–1983; birth name was Josephine) was a Mexican-born Anglo-American playwright and novelist. Writing about Mexican-American issues in the middle years of the century, before the rise of the Chicano movement, she was the first and, for a time, the only Mexican American writing in English on Mexican themes; her egalitarian views of gender, race and ethnicity were progressive for their time and helped lay the groundwork for such later Chicana feminists as Gloria Anzaldúa, Ana Castillo and Sandra Cisneros. Niggli is now recognized as "a literary voice from the middle ground between Mexican and Anglo heritage." Critic Elizabeth Coonrod Martinez has written that Niggli should be considered on a par with such widely praised Spanish-language contemporaries as Mariano Azuela, Martín Luis Guzmán and Nellie Campobello. She is thought to be the only Mexican-American woman to have a theatre named after her, the Niggli Studio Theater at Western Carolina University.

Mario Héctor Gottfried Gutiérrez (September 7, 1919 – November 2, 1999,) was a businessman in the Mexican electric industry, and captain of the Air Force of the United States. Founder of a group of Mexican companies, such as Reliance de Mexico, S.A. de C.V., and Potencia Industrial, S.A.

Alexander Cañedo (December 26, 1902 – February 1, 1978) was a Mexican-American artist who was part of the surrealism and magic realism art movements of the mid-20th century.

Alberto Braniff Ricard (8 December 1886 – 17 September 1966) was a Mexican pioneering airplane pilot. He is considered the second aviator in Latin America, however the first born in Latin America.

Sarah Elizabeth Stewart (August 16, 1905 – November 27, 1976) was a Mexican-American researcher who pioneered the field of viral oncology research, and the first to show that cancer-causing viruses can spread from animal to animal. She and Bernice Eddy co-discovered the first polyoma virus, and SE (Stewart-Eddy) polyoma virus is named after them.