Physicians from Mainz

Karl Mellinger (26 November 1858, in Mainz – 21 May 1917, in Basel) was a German-Swiss ophthalmologist.
Mellinger studied medicine at the universities of Zürich and Basel until 1883, and afterwards worked as an assistant to ophthalmologists Johann Friedrich Horner in Zürich and Karl Stellwag von Carion at the University of Vienna. In 1889 he obtained his habilitation at Basel and was named head of the outpatient clinic. In 1896 he became an associate professor and successor to Heinrich Schiess-Gemuseus as head of the university eye clinic. Among his students and assistants at Basel were Alfred Vogt and August Siegrist. He is credited with introducing a specialized ring magnet (inner pole eye magnet) into ophthalmology.

Gustav Killian (2 June 1860 – 24 February 1921) was a German laryngologist and founder of the bronchoscopy.

Carl von Hess (7 March 1863, in Mainz – 28 June 1923, in Possenhofen) was a German ophthalmologist known for his work in ocular physiology.
He studied medicine at the universities of Heidelberg, Bonn and Strasbourg, then traveled to Prague, where he worked with ophthalmologist Hubert Sattler and physiologist Ewald Hering. In 1891 he obtained his habilitation from the University of Leipzig, and later on, he held professorships at the universities of Marburg (from 1896), Würzburg (from 1900) and Munich (from 1912).He made significant contributions in his studies of refraction and accommodation of the eye. He also conducted research on color vision in the various retinal zones, on the various forms of color blindness, of simultaneous contrast, on afterimages of moving objects and of light-dark adaptation. In addition, he performed comparative physiological studies on light sense and color vision involving animals, in invertebrates as well as vertebrates. Along with Paul Römer, he made the discovery that trachoma is transmissible to monkeys.His name is associated with the "Hess afterimage", defined as a positive afterimage that occurs third in the series of afterimages that are the result of exposure to a brief light stimulus (sequentially, the first afterimage is referred to as a "Hering afterimage", the second as a "Purkinje afterimage"). The Hess afterimage is defined as a physiological illusion. There are also several surgical instruments that are named after him.