People from Mayag\u00fcez

Rafael López Nussa (22 February 1885 – 3 March 1943) was a Puerto Rican physician and public servant. In 1916 López Nussa performed the first heart surgery operation in Puerto Rico.

José M. Cabanillas (September 23, 1901 – September 15, 1979), was a rear admiral in the United States Navy who as an executive officer of the USS Texas participated in the invasions of North Africa and the Battle of Normandy (also known as D-Day) during World War II.

José Leandro Montalvo Guenard (1885 – 1950) was a Puerto Rican physician, inventor, anthropologist and historian. He is known for his "Rectificaciones Históricas: El Descubrimiento de Boriquén", published by Editorial del Llano, in Ponce, Puerto Rico, in 1933.

Gilbert Mamery Riera (March 15, 1927 – March 30, 2003) was a Puerto Rican disc-jockey, musicologist, radio station owner, radio and television personality, marketing impresario and composer born in Mayagüez, Puerto Rico. He is the father of the late Puerto Rican talent manager and radio entrepreneur Topy Mamery, Puerto Rican radio announcer and marketing impresario Eric William Mamery, and media announcer and comedian Gricel Mamery. He was also the son of Lebanese-born textile impresario William Mamary (the family name's spelling was later changed during Gilbert's lifetime).