People from San Juan

Cristina Arámbulo Villanueva Manalo (born February 1, 1937, in Manila, Philippines), popularly known as Ka Tenny Manalo, is the widow of former Iglesia ni Cristo (INC) executive minister Eraño G. Manalo. She stood a loyal wife beside her husband who led the church for over 46 years, from the death of Felix Manalo in 1963 and until the latter's death in 2009. Her eldest son, Eduardo V. Manalo, who was at the time deputy executive minister, assumed the post seven days after his predecessor's demise.In the midst of the INC leadership controversy in 2015, Tenny was excommunicated (expelled). It was announced through circulars on regular worship services of July 23 to 25, signed by INC Secretary-General Radel G. Cortez with the approval of Executive Minister Eduardo Manalo. Lolita "Lottie" Manalo-Hemedez, Felix Nathaniel "Angel" Manalo and Marco Eraño Manalo were also expelled on the grounds of violating the doctrine on unity, INC's 22nd principal doctrine.

Edward G. Miller Jr. (September 27, 1911 – April 15, 1968) was a United States lawyer who served as Assistant Secretary of State for Inter-American Affairs from 1949 to 1952.

Spencer Matthews King (August 11, 1917 in San Juan, Puerto Rico – January 20, 1988) was a U.S. Ambassador to Guyana. Appointed by President Richard Nixon on May 27, 1969, he presented his credentials to Governor-General Sir Richard Edmonds Luyt on October 15, 1969, in the capital city of Georgetown. After Guyana declared itself a republic in 1970, Ambassador King had to be reaccredited as ambassador, this time presenting his credentials to the republic's new president, Sir Edward Victor Luckhoo on February 23, 1970. He represented the United States and its interests in this former British colony until March 8, 1974, when he left the post. A longtime resident of Maine, he retired from the foreign service after his ambassadorship came to an end. He died on January 20, 1988.

Ricardo E. Alegría Gallardo (April 14, 1921 – July 7, 2011) was a Puerto Rican scholar, cultural anthropologist and archaeologist known as the "father of modern Puerto Rican archaeology".

Ernesto Pastor Lavergne (April 4, 1892 - June 11, 1921) was the first of only two Puerto Rican-born bullfighters (toreros) to gain international fame, the other being Juan Ramón Fernandez.