2006 in Massachusetts

Rebecca Jeanne Riley (April 11, 2002 – December 13, 2006) was a four-year-old girl from Massachusetts. In December 2006, Riley's parents gave Riley—who had been diagnosed with attention-deficit hyperactivity disorder and pediatric bipolar disorder between two and three years old—a lethal dose of clonidine. Her death sparked significant controversy over diagnosis of psychiatric conditions and subsequent prescription of psychotropic medication in children.

Neil Entwistle (born 18 September 1978) is an English man convicted of murdering his American wife, Rachel, and their infant daughter, Lillian, on 20 January 2006, in Hopkinton, Massachusetts, United States. He was sentenced to life imprisonment without parole and is incarcerated at Old Colony Correctional Center in Bridgewater, Massachusetts.