Scientists from Frankfurt

Alexander Ellinger (17 April 1870 in Frankfurt am Main – 26 July 1923 in Frankfurt am Main) was a German chemist and pharmacologist.
From 1887 he studied chemistry at the University of Berlin under August Wilhelm von Hofmann and at the University of Bonn as a pupil of August Kekulé. Afterwards, he studied medicine at the University of Munich, followed by work as an assistant in the institute of pharmacology at the University of Strasbourg. In 1897 he became an assistant to Max Jaffé in the laboratory of medicinal chemistry and experimental pharmacology at the University of Königsberg. In 1914 he was appointed professor of pharmacology at the newly established University of Frankfurt.He is remembered for his extensive biochemical research of several amino acids, especially tryptophan. In 1904 he isolated kynurenic acid from the urine of dogs that had been fed tryptophan. His other work included studies on the water exchange between body tissues and blood, on the formation on lymph, and with chemist Karl Spiro, he conducted investigations of blood coagulation.

Wilhelm Hermann Julius Eitel (6 May 1891, Frankfurt am Main – 20 July 1979, United States) was a German-American scientist.

Walther Gerlach (1 August 1889 – 10 August 1979) was a German physicist who co-discovered, through laboratory experiment, spin quantization in a magnetic field, the Stern–Gerlach effect. The experiment was conceived by Otto Stern in 1921 and successfully conducted first by Gerlach in early 1922.

Richard Benedict Goldschmidt (April 12, 1878 – April 24, 1958) was a German geneticist. He is considered the first to attempt to integrate genetics, development, and evolution. He pioneered understanding of reaction norms, genetic assimilation, dynamical genetics, sex determination, and heterochrony. Controversially, Goldschmidt advanced a model of macroevolution through macromutations popularly known as the "Hopeful Monster" hypothesis.Goldschmidt also described the nervous system of the nematode, a piece of work that influenced Sydney Brenner to study the "wiring diagram" of Caenorhabditis elegans, winning Brenner and his colleagues the Nobel Prize in 2002.

August Friedrich Leopold Weismann FRS (For), HonFRSE, LLD (17 January 1834 – 5 November 1914) was a German evolutionary biologist. Fellow German Ernst Mayr ranked him as the second most notable evolutionary theorist of the 19th century, after Charles Darwin. Weismann became the Director of the Zoological Institute and the first Professor of Zoology at Freiburg.
His main contribution involved germ plasm theory, at one time also known as Weismannism, according to which inheritance (in a multicellular animal) only takes place by means of the germ cells—the gametes such as egg cells and sperm cells. Other cells of the body—somatic cells—do not function as agents of heredity. The effect is one-way: germ cells produce somatic cells and are not affected by anything the somatic cells learn or therefore any ability an individual acquires during its life. Genetic information cannot pass from soma to germ plasm and on to the next generation. Biologists refer to this concept as the Weismann barrier. This idea, if true, rules out the inheritance of acquired characteristics as proposed by Jean-Baptiste Lamarck. However, a careful reading of Weismann's work over the span of his entire career shows that he had more nuanced views, insisting, like Darwin, that a variable environment was necessary to cause variation in the hereditary material.The idea of the Weismann barrier is central to the modern synthesis of the early 20th century, though scholars do not express it today in the same terms. In Weismann's opinion the largely random process of mutation, which must occur in the gametes (or stem cells that make them) is the only source of change for natural selection to work on. Weismann became one of the first biologists to deny Lamarckism entirely. Weismann's ideas preceded the rediscovery of Gregor Mendel's work, and though Weismann was cagey about accepting Mendelism, younger workers soon made the connection.
Weismann is much admired today. Ernst Mayr judged him to be the most important evolutionary thinker between Darwin and the evolutionary synthesis around 1930–1940, and "one of the great biologists of all time".