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The University of California, San Francisco Medical Center is a research and teaching hospital in San Francisco, California and is the medical center of the University of California, San Francisco. It is affiliated with the UCSF School of Medicine. In 2022–23, it was ranked as the 12th-best overall hospital in the United States and one of the top three hospital in California by U.S. News & World Report.It was founded in 1907 at the site of Parnassus Heights, on Mount Sutro, following the 1906 earthquake, and it was the first hospital in the University of California system. The university acquired Mount Zion Hospital in 1990, which became the second major clinical site and since 1999 has hosted the first comprehensive cancer center in Northern California. Beginning in 2001, the university expanded in the Mission Bay neighborhood and added a new medical center with three new hospitals.