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The Mary Erskine School, popularly known as "Mary Erskine's" or "MES", is an all-girls private secondary school in Edinburgh, Scotland. It was founded in 1694 and has a roll of around 750 pupils. It is the sister school of the all-boys Stewart's Melville College (SMC) with which MES shares a coeducational nursery and junior school for pupils aged 3–11.The majority of its pupils live in the surrounding area (Edinburgh, Lothian and Fife) but boarding facilities are available. About 3% of the pupils are boarders. The school is non-denominational but claims to have a broadly Christian outlook.
Both MES and SMC are managed by the Merchant Company of Edinburgh which is also responsible for the city's George Watson's College. In 2014 the combined Erskine Stewarts Melville school claimed to be the largest independent school in Europe.Although the school is single sex, some activities, although not teaching, are carried out jointly with the boys from SMC. The sixth (final) year of the school is co-educational.