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The Archdiocese of Matera-Irsina (Latin: Archidioecesis Materanensis-Montis Pelusii) is a Latin archdiocese of the Catholic Church in Basilicata, Italy. It has existed under this name since 1986. The archbishop is seated at Matera Cathedral. (Irsina Cathedral is a co-cathedral). It is a suffragan of the Archdiocese of Potenza-Muro Lucano-Marsico Nuovo.
On Monday, October 5, 2015, Archbishop Salvatore Ligorio was elevated by Pope Francis to be Metropolitan Archbishop of the Roman Catholic Archdiocese of Potenza-Muro Lucano-Marsico Nuovo (in Potenza, Italy), to whose province the Archdiocese of Matera-Irsina (in Matera, Italy, and Irsina, Italy) belongs. It is not the norm, but by no means irregular to have a non-metropolitan archdiocese under a metropolitan archdiocese.