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Our Lady of Pompeii Church, or more formally, the Shrine Church of Our Lady of Pompeii, is a Catholic parish church located in the South Village neighborhood of Manhattan, New York City, in the United States. The church is staffed by Scalabrini Fathers, while the Our Lady of Pompeii School is staffed by Apostles of the Sacred Heart of Jesus. It is located across from Father Demo Square, which is named for the church's third pastor, Antonio Demo.
The church was founded in 1892 as a national parish to serve Italian-American immigrants who settled in Greenwich Village, eventually becoming the American counterpart to the Shrine of Our Lady of the Rosary of Pompei in Italy and a shrine in its own right. The church has resided at its present location since 1926, when construction on its current edifice began. While it has remained a largely Italian American parish, the church has come to incorporate many other immigrant groups.