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Major Lee Applewhite (born July 26, 1978) is an American football coach and former player who is currently the head coach for the South Alabama Jaguars. He served as head coach at the University of Houston from 2017 to 2018, where he previously served as the offensive coordinator and quarterbacks coach. In 2013, he was the co-offensive coordinator and quarterbacks coach at the University of Texas under his head coach as a player, Mack Brown. Prior to Texas, Applewhite served as offensive coordinator at Rice University under Todd Graham in 2006 and at Alabama under Nick Saban in 2007. He was the youngest offensive coordinator among Division I-A schools at that time.
Applewhite was the quarterbacks coach at Syracuse University in 2005. Prior to coaching, he was a college football quarterback for the Texas Longhorns from 1998 to 2001 and set eight school records. Many of these still stand, including the longest pass play (97 yards), and most yards passing in a game (473). He previously held the record for career yards (8,353) and consecutive passes without an interception (156).