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Catharina Elisabeth Godefrida "Karien" van Gennip (born 3 October 1968) is a Dutch businesswoman and politician who has served as Minister of Social Affairs and Employment in the Fourth Rutte cabinet since 10 January 2022. She is a member of the Christian Democratic Appeal (CDA).
A native of Leidschendam, Karien van Gennip worked at McKinsey & Company and the Netherlands Authority for the Financial Markets until she entered politics when she was appointed State Secretary for Economic Affairs in 2003 under Jan Peter Balkenende's second cabinet, a position she retained under his third cabinet until 2007. In the 2006 general election, she was elected to the House of Representatives. She resigned in 2008 to continue her business career at ING until her return to politics in 2022.