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David Da-i Ho (Chinese: 何大一; born November 3, 1952) is a Taiwanese American AIDS researcher, physician, and virologist who has made a number of scientific contributions to the understanding and treatment of HIV infection. He championed for combination anti-retroviral therapy instead of single therapy, which turned HIV from absolute terminal disease into a chronic disease.David Ho was born in Taiwan in 1952 and immigrated to the United States in 1965, where he was educated at California Institute of Technology and Harvard Medical School (through the Harvard–MIT Program in Health Sciences and Technology) before getting his clinical training at UCLA School of Medicine and Massachusetts General Hospital.
He is the founding scientific director of the Aaron Diamond AIDS Research Center and the Clyde and Helen Wu Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, both housed at Columbia University Irving Medical Center.