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Sandra Spuzich (April 3, 1937 – October 6, 2015) was an American professional golfer who played on the LPGA Tour in the 1960s, 1970s and 1980s.
Spuzich was born in Indianapolis, Indiana, of Polish, Serbian, Macedonian and Lebanese descent. She was an amateur golfer and elementary school teacher when she decided to turn professional in 1962. Her first win came at the 1966 U.S. Women's Open by one stroke over Carol Mann and two strokes over Mickey Wright. The tournament was held at Hazeltine National Golf Club in Chaska, Minnesota – the first major championship played there.
In 1982 at the age of 45, Spuzich became the oldest player to win two LPGA Tour events in the same year when she won the Corning Classic followed by the Mary Kay Classic.Spuzich died in Indianapolis on October 6, 2015. Her life partner was fellow LPGA golfer Joyce Kazmierski.