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Karyn Kupcinet (born Roberta Lynn Kupcinet; March 6, 1941 – November 28, 1963) was an American stage, film, and television actress. She was the daughter of Chicago newspaper columnist and television personality Irv Kupcinet, and the sister of television director and producer Jerry Kupcinet.
Kupcinet had a brief acting career during the early 1960s. Six days after the assassination of John F. Kennedy, her body was found at her home in West Hollywood, California. With her death officially ruled an unsolved homicide, and occurring so close to the assassination, her name became one of hundreds added to the multiplicity of theories that emerged after the assassination.
Kupcinet's father publicly dismissed the theories linking his daughter to the president's death. In 1992, after NBC's Today program briefly referred via a caption to her alleged connection to the assassination, Irv Kupcinet described the broadcast as "an atrocious outrage" and "calumny". Karyn Kupcinet's death remains officially unsolved.